English: Blocking the Na+/K+ pump with ouabain evokes an AD-like response in a live coronal slice. Image sequence showing an AD front propagating at 2–3 mm/minute through neocortical gray and then through striatum. The wave of elevated LT is induced at about 5 minutes of bath exposure to 100 µM ouabain. By 6 minutes the LT reduction (pseudocolored purple denoting neuronal injury) slowly increases in the wake of AD. By the end of video, ouabain (applied for 10 minutes) has been washed out for 30 minutes with no recovery. This LT sequence is similar to responses evoked by OGD (Fig. 1A; Movie S1) or palytoxin (Fig. 1B).