File:Distinct-APC-Subtypes-Drive-Spatially-Segregated-CD4+-and-CD8+-T-Cell-Effector-Activity-during-Skin-ppat.1004303.s009.ogv

Distinct-APC-Subtypes-Drive-Spatially-Segregated-CD4+-and-CD8+-T-Cell-Effector-Activity-during-Skin-ppat.1004303.s009.ogv(Ogg Theora video file, length 9.0 s, 506 × 504 pixels, 1.31 Mbps, file size: 1.4 MB)


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Summary

Description
English: Reduced velocity of CD8+ TEFF cells in proximity to HSV-infected cells. Wild-type mice were subjected to skin infection with HSV.CFP and received in vitro activated gBT-I cells 3 days post-infection. A representative 59 min time-lapse movie of infected skin taken 5 days post-infection. The second harmonic generation signal (2HG) marks the collagen-rich dermal layer. The time-lapse is shown at 8 frames per second. Movie is representative of 8 movies from n = 4 mice from 2 experiments. Scale bar, 30 µm.
Date
Source Movie S1 from Macleod B, Bedoui S, Hor J, Mueller S, Russell T, Hollett N, Heath W, Tscharke D, Brooks A, Gebhardt T (2014). "Distinct APC Subtypes Drive Spatially Segregated CD4+ and CD8+ T-Cell Effector Activity during Skin Infection with HSV-1". PLOS Pathogens. DOI:10.1371/journal.ppat.1004303. PMID 25121482. PMC: 4133397.
Author Macleod B, Bedoui S, Hor J, Mueller S, Russell T, Hollett N, Heath W, Tscharke D, Brooks A, Gebhardt T
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This file was transferred to Wikimedia Commons from PubMed Central by way of the Open Access Media Importer.
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August 2014

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current20:12, 21 August 20149.0 s, 506 × 504 (1.4 MB)Open Access Media Importer BotAutomatically uploaded media file from Open Access source. Please report problems or suggestions here.

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