File:Triad chemical mech.png

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Summary

DescriptionTriad chemical mech.png	English: A catalytic triad charge-relay system as commonly found in proteases. The acid residue (commonly glutamate or aspartate) aligns and polarises the base (usually histidine) which activates the nucleophile (often serine or cysteine, occasionally threonine). The catalytic triad reduces the pKa of the nucleophilic residue which then performs a nucleophilic attack on the substrate.
Date	23 October 2013, 20:35:38
Source	Thomas, Shafee, (2014). "Evolvability of a viral protease: experimental evolution of catalysis, robustness and specificity". PhD Thesis. University of Cambridge.
Author	Thomas Shafee

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	Date/Time	Dimensions	User	Comment
current	20:24, 23 October 2013	566 × 267 (7 KB)	Evolution and evolvability	small edit to nucleophile
	19:57, 23 October 2013	566 × 267 (7 KB)	Evolution and evolvability	wider
	19:50, 23 October 2013	346 × 262 (7 KB)	Evolution and evolvability	User created page with UploadWizard

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